Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons.

@article{Ator2005SelfinjectionOF,
  title={Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons.},
  author={Nancy A. Ator and Roland R Griffiths and Elise M Weerts},
  journal={Drug and alcohol dependence},
  year={2005},
  volume={78 2},
  pages={
          113-23
        }
}
Patients in methadone maintenance programs use benzodiazepines to "boost" methadone's subjective effects, and flunitrazepam has been prominent in this context. Self-administration of flunitrazepam (0.001-0.32 mg/kg i.v.) alone and during daily oral methadone administration was evaluated in three baboons. Flunitrazepam maintained self-injection as an inverted U-shaped function of dose at rates higher than those maintained by most other benzodiazepines under the same procedure. In the context of… CONTINUE READING
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