Self-injection of diazepam in naive rats: Effects of dose, schedule and blockade of different receptors

@article{Pilotto1984SelfinjectionOD,
  title={Self-injection of diazepam in naive rats: Effects of dose, schedule and blockade of different receptors},
  author={Rudy Pilotto and George Singer and David E Overstreet},
  journal={Psychopharmacology},
  year={1984},
  volume={84},
  pages={174-177}
}
The present series of experiments had two main objectives: The first was to determine the conditions under which self-injection of the benzodiazepine diazepam would be optimal; the second was to identify neurochemical substrates which underlie the maintenance of diazepam selfadministration. Data from the first experiment indicated that rats maintained on an FI-1 (Fixed Interval of 1 min) schedule of food delivery self-injected significantly more diazepam than rats not maintained on this… CONTINUE READING

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