Self-healing microencapsulation of biomacromolecules without organic solvents.

@article{Reinhold2012SelfhealingMO,
  title={Self-healing microencapsulation of biomacromolecules without organic solvents.},
  author={Samuel E. Reinhold and Kashappa-Goud H. Desai and Li Zhang and Karl C F Olsen and Steven P Schwendeman},
  journal={Angewandte Chemie},
  year={2012},
  volume={51 43},
  pages={
          10800-3
        }
}
Microencapsulation of biomacromolecules in PLGA is routinely performed with organic solvent through multiple complex steps deleterious to the biomacromolecule. The new self-healing based PLGA microencapsulation obviates micronization- and organic solvent-induced protein damage, provides very high encapsulation efficiency, exhibit stabilization and slow release of labile tetanus protein antigen, and provides long-term testosterone suppression in rats following a single injection of encapsulated… CONTINUE READING
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