Self-encapsulating Poly(lactic-co-glycolic acid) (PLGA) Microspheres for Intranasal Vaccine Delivery.

@article{Bailey2017SelfencapsulatingPA,
  title={Self-encapsulating Poly(lactic-co-glycolic acid) (PLGA) Microspheres for Intranasal Vaccine Delivery.},
  author={Brittany Agius Bailey and Kashappa-Goud H. Desai and Lukasz J. Ochyl and Susan Marie Ciotti and James J Moon and Steven P Schwendeman},
  journal={Molecular pharmaceutics},
  year={2017},
  volume={14 9},
  pages={
          3228-3237
        }
}
Herein we describe a formulation of self-encapsulating poly(lactic-co-glycolic acid) (PLGA) microspheres for vaccine delivery. Self-healing encapsulation is a novel encapsulation method developed by our group that enables the aqueous loading of large molecules into premade PLGA microspheres. Calcium phosphate (CaHPO4) adjuvant gel was incorporated into the microspheres as a protein-trapping agent for improved encapsulation of antigen. Microspheres were found to have a median size of 7.05 ± 0.31… CONTINUE READING
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