Self-eating and self-killing: crosstalk between autophagy and apoptosis

@article{Maiuri2007SelfeatingAS,
  title={Self-eating and self-killing: crosstalk between autophagy and apoptosis},
  author={Maria Chiara Maiuri and Einat Zalckvar and Adi Kimchi and Guido Kroemer},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={741-752}
}
The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell… Expand

Figures and Topics from this paper

Molecular Cross-Talk between the Autophagy and Apoptotic Networks in Cancer
TLDR
Autophagy appears to have a dual role in cancer, as it has now been shown to facilitate the survival of tumor cells in stress conditions such as hypoxic or low-nutrition environments. Expand
Self-consumption: the interplay of autophagy and apoptosis
TLDR
The dialogue between autophagy and cell death pathways influences the normal clearance of dying cells, as well as immune recognition of dead cell antigens, and the disruption of the relationship between autphagy and apoptosis has important pathophysiological consequences. Expand
Self‐eating and self‐defense: autophagy controls innate immunity and adaptive immunity
TLDR
A review of the recent findings regarding the regulatory and mechanistic insights of the autophagy pathway in immunity shows that a self‐eating (autophagy) process could regulate a self-defense (immune) system. Expand
Autophagy in aging, disease and death: the true identity of a cell death impostor
TLDR
A consensus is emerging that autophagy is largely a cell death impostor which, in reality, functions primarily to promote cellular and organismal health. Expand
Autophagy, Cell Death, and Cancer
TLDR
Depending on the stage of tumor progression, autophagy can act as a tumor-suppressor mechanism or can help tumor cells cope with stressful situations generated by the tumoral environment or cancer treatment. Expand
The cellular decision between apoptosis and autophagy
TLDR
This review summarizes recent literature on molecules that regulate both the apoptotic and autophagic processes and indicates an interplay between the core proteins in both pathways, which underlies the molecular mechanism of the crosstalk between apoptosis and Autophagy. Expand
Autophagy fights disease through cellular self-digestion
TLDR
Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death. Expand
The Cross Talk Between Apoptosis and Autophagy
The cross talk between autophagy and apoptosis is complex. Autophagy serves as a cytoprotective mechanism in response to stress to generate nutrients during starvation, remove damaged proteins andExpand
The Nuptials of Autophagy and Apoptosis –A Review
Autophagy is a widely conserved catabolic process that is essential for maintaining cellular homeostasis under normal physiological conditions and driving the cell to switch back to this conditionExpand
Survival by self-destruction: a role for autophagy in the placenta?
TLDR
The regulation ofautophagy is reviewed, available placental studies of autophagy are summarized, and potential areas for future research are highlighted to yield novel insights into how placentas protect the survival of the species by "self-eating". Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 107 REFERENCES
Autophagy: dual roles in life and death?
  • E. Baehrecke
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 2005
TLDR
The possible roles for autophagy in dying cells are discussed and how understanding the relationship betweenautophagy, cell survival and cell death is important for health and development is discussed. Expand
Autophagy and cell death.
TLDR
This chapter aims at summarizing the recent data in the field of autophagy signaling and autophagic cell death, and recognized now as a legitimate alternative death pathway to apoptosis. Expand
Autophagy in cell death: an innocent convict?
The visualization of autophagosomes in dying cells has led to the belief that autophagy is a nonapoptotic form of programmed cell death. This concept has now been evaluated using cells and organismsExpand
Development by self-digestion: molecular mechanisms and biological functions of autophagy.
TLDR
This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy. Expand
Autophagy in Health and Disease: A Double-Edged Sword
TLDR
Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process. Expand
The role of autophagy in cancer development and response to therapy
TLDR
It is still unclear whether autophagy suppresses tumorigenesis or provides cancer cells with a rescue mechanism under unfavourable conditions, and how can the autophagic process be manipulated to improve anticancer therapeutics. Expand
Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8
TLDR
A new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy is defined. Expand
Inactivation of the Autophagy Gene bec-1 Triggers Apoptotic Cell Death in C. elegans
TLDR
It is proposed that bec-1 represents a link between autophagy and apoptosis, thus supporting the view that the two processes act in concerted manner in the cell death machinery. Expand
Autophagic programmed cell death by selective catalase degradation.
  • L. Yu, F. Wan, +5 authors M. Lenardo
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
It is shown that caspase inhibition leading to cell death by means of autophagy involves reactive oxygen species (ROS) accumulation, membrane lipid oxidation, and loss of plasma membrane integrity. Expand
Autophagy in neurons: it is not all about food.
  • A. Cuervo
  • Biology, Medicine
  • Trends in molecular medicine
  • 2006
TLDR
Using genetic manipulations to block autophagy in neurons selectively, Mizushima's and Tanaka's groups have recently presented conclusive evidence for an essential role of constitutive autophagic in neuronal survival. Expand
...
1
2
3
4
5
...