Self-eating and self-killing: crosstalk between autophagy and apoptosis

@article{Maiuri2007SelfeatingAS,
  title={Self-eating and self-killing: crosstalk between autophagy and apoptosis},
  author={M. Maiuri and E. Zalckvar and A. Kimchi and G. Kroemer},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={741-752}
}
  • M. Maiuri, E. Zalckvar, +1 author G. Kroemer
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell… CONTINUE READING
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    References

    SHOWING 1-10 OF 107 REFERENCES
    Autophagy: dual roles in life and death?
    • E. Baehrecke
    • Biology, Medicine
    • Nature Reviews Molecular Cell Biology
    • 2005
    • 891
    Autophagy and cell death.
    • 484
    • PDF
    Autophagy in cell death: an innocent convict?
    • 1,618
    • PDF
    Autophagy in Health and Disease: A Double-Edged Sword
    • 2,226
    The role of autophagy in cancer development and response to therapy
    • 1,461
    Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8
    • 1,199
    Autophagic programmed cell death by selective catalase degradation.
    • L. Yu, F. Wan, +5 authors M. Lenardo
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2006
    • 601
    • PDF