Self-eating and self-killing: crosstalk between autophagy and apoptosis

  title={Self-eating and self-killing: crosstalk between autophagy and apoptosis},
  author={M. Maiuri and E. Zalckvar and A. Kimchi and G. Kroemer},
  journal={Nature Reviews Molecular Cell Biology},
  • M. Maiuri, E. Zalckvar, +1 author G. Kroemer
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell… CONTINUE READING
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