Self-defensive layer-by-layer films with bacteria-triggered antibiotic release.

  title={Self-defensive layer-by-layer films with bacteria-triggered antibiotic release.},
  author={Iryna Zhuk and Freneil B. Jariwala and Athula B Attygalle and Yong Wu and Matthew Libera and Svetlana A Sukhishvili},
  journal={ACS nano},
  volume={8 8},
We report on highly efficient, bioresponsive, controlled-release antibacterial coatings constructed by direct assembly of tannic acid (TA) with one of several cationic antibiotics (tobromycin, gentamicin, and polymyxin B) using the layer-by-layer (LbL) technique. These films exhibit a distinct “self-defense” behavior triggered by acidification of the immediate environment by pathogenic bacteria, such as Staphylococcus epidermidis (S. epidermidis) or Escherichia coli (E. coli). Films assembled… CONTINUE READING
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