Self-contained, biomolecular motor-driven protein sorting and concentrating in an ultrasensitive microfluidic chip.

@article{Lin2008SelfcontainedBM,
  title={Self-contained, biomolecular motor-driven protein sorting and concentrating in an ultrasensitive microfluidic chip.},
  author={Chih-Ting Lin and Ming-Tse Kao and Katsuo Kurabayashi and Edgar Meyhofer},
  journal={Nano letters},
  year={2008},
  volume={8 4},
  pages={
          1041-6
        }
}
We developed a molecular sorter that operates without external power or control by integrating the microtubule-based, biological motor kinesin into a microfluidic channel network to sort, transport, and concentrate molecules. In our devices, functionalized microtubules that capture analyte molecules are steered along kinesin-coated microchannel tracks toward a collector structure, concentrated, and trapped. Using fluorescent analyte molecules and nanoliter sample volumes, we demonstrated 14 fM… CONTINUE READING
BETA

Figures and Topics from this paper.

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Translational actomyosin research: fundamental insights and applications hand in hand

  • Journal of Muscle Research and Cell Motility
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Protein-based Engineered Nanostructures

  • Advances in Experimental Medicine and Biology
  • 2016