Self-compartmentalized bacterial proteases and pathogenesis.

  title={Self-compartmentalized bacterial proteases and pathogenesis.},
  author={Susan M. Butler and Richard A. Festa and Michael J. Pearce and K. Heran Darwin},
  journal={Molecular microbiology},
  volume={60 3},
Protein degradation is required for homeostasis of all living organisms. Self-compartmentalized ATP-dependent proteases are required for virulence of several pathogenic bacteria. Among the proteases implicated are ClpP and Lon, as well as the more recently identified bacterial proteasome. It is generally assumed that when a pathogen invades a host, microbial proteins become irreversibly damaged and need to be degraded. However, recent data suggest that proteolysis is also essential for… CONTINUE READING

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