Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.

  title={Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.},
  author={Paul R. Ortiz de Montellano and Kent L. Kunze},
  journal={The Journal of biological chemistry},
  volume={255 12},
The following acetylenic substrates have been shown to mediate NADPH-dependent loss of cytochrome P450 on incubation with hepatic microsomes from phenobarbital-pretreated rats: 1-ethynylcyclohexanol, 1ethynylcyclopentanol, 3-methyl-1-pentyn-3-01, norethisterone, (1-methoxycyclohexyl)acetylene, 3-(2,4-dichlorophenoxy)-1-propyne, 3-(4-nitrophenoxy)-l-propyne, 3-phenoxy-l-propyne, 4-phenyl-l-butyne, 3phenyl-1-propyne, cyclohexylacetylene, acetylene, 3pentyn-2-01, 4-methyl-2-octyn-4-01, 2-hexyne, p… CONTINUE READING
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