Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency.

@article{Virg2009SelfaugmentationOT,
  title={Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency.},
  author={L{\'a}szl{\'o} Vir{\'a}g and K{\'a}roly Acsai and Ott{\'o} H{\'a}la and Antonio Zaza and Mikl{\'o}s Bitay and G{\'a}bor Bog{\'a}ts and Julius Gy Papp and Andr{\'a}s Varr{\'o}},
  journal={British journal of pharmacology},
  year={2009},
  volume={156 7},
  pages={1076-84}
}
BACKGROUND AND PURPOSE The aims of the present work were to study the mechanism of the reverse rate dependency of different interventions prolonging cardiac action potential duration (APD). EXPERIMENTAL APPROACH The reverse rate-dependent lengthening effect of APD-prolonging interventions and the possible involvement of I(Kr) (rapid component of the delayed rectifier potassium current) and I(K1) (inward rectifier potassium current) were studied by using the standard microelectrode and the… CONTINUE READING
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