Self-association of the Shigella flexneri IcsA autotransporter protein.

@article{May2012SelfassociationOT,
  title={Self-association of the Shigella flexneri IcsA autotransporter protein.},
  author={Kerrie L May and Marcin Grabowicz and Steven W Polyak and Renato Morona},
  journal={Microbiology},
  year={2012},
  volume={158 Pt 7},
  pages={
          1874-83
        }
}
The IcsA autotransporter protein is a major virulence factor of the human intracellular pathogen Shigella flexneri. IcsA is distributed at the poles in the outer membrane (OM) of S. flexneri and interacts with components of the host actin-polymerization machinery to facilitate intracellular actin-based motility and subsequent cell-to-cell spreading of the bacterium. We sought to characterize the biochemical properties of IcsA in the bacterial OM. Chemical cross-linking data suggested that IcsA… CONTINUE READING

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