Self-association of short DNA loops through minor groove C:G:G:C tetrads

  title={Self-association of short DNA loops through minor groove C:G:G:C tetrads},
  author={J{\'u}lia Viladoms and N Escaja and M. Frieden and Irene G{\'o}mez-Pinto and Enrique Pedroso and Carlos Gonz{\'a}lez},
  booktitle={Nucleic acids research},
In addition to the better known guanine-quadruplex, four-stranded nucleic acid structures can be formed by tetrads resulting from the association of Watson-Crick base pairs. When such association occurs through the minor groove side of the base pairs, the resulting structure presents distinctive features, clearly different from quadruplex structures containing planar G-tetrads. Although we have found this unusual DNA motif in a number of cyclic oligonucleotides, this is the first time that this… CONTINUE READING


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