Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.

@article{Oikawa2007SelfassociationAB,
  title={Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.},
  author={Daisuke Oikawa and Yukio Kimata and Kenji Kohno},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 9},
  pages={1681-8}
}
Ire1 is a type I transmembrane protein located on the endoplasmic reticulum (ER). Upon ER stress, Ire1 releases the ER chaperone BiP and self-associates. This activates Ire1 and triggers the unfolded protein response in the yeast Saccharomyces cerevisiae. We isolated and characterized an Ire1 luminal domain mutant lacking both the N-terminal and the… CONTINUE READING