Self-assembly of laminin isoforms.

  title={Self-assembly of laminin isoforms.},
  author={Yinghong Cheng and M F Champliaud and Robert E. Burgeson and Matt Peter Marinkovich and Peter D Yurchenco},
  journal={The Journal of biological chemistry},
  volume={272 50},
The alpha, beta, and gamma subunits of basement membrane laminins can combine into different heterotrimeric molecules with either three full short arms (e.g. laminins-1-4), or molecules containing one (laminins-6-9) or more (laminin-5) short arm truncations. Laminin-1 (alpha1beta1gamma1), self-assembles through a calcium-dependent thermal gelation requiring binding interactions between N-terminal short arm domains, forming a meshwork polymer thought to contribute to basement membrane… CONTINUE READING
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Extracellular Matrix Assembly and Structure (Yurchenco

  • U. Mayer, R. Timpl
  • 1994

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