Self assembly of human septin 2 into amyloid filaments.

  title={Self assembly of human septin 2 into amyloid filaments.},
  author={Julio Cesar Pissuti Damalio and Wanius Garcia and Joci Neuby Alves Mac{\^e}do and Ivo de Almeida Marques and Jos{\'e} M Andreu and Rafael Giraldo and Richard Garratt and Ana Paula Ulian Ara{\'u}jo},
  volume={94 3},
Septins are a conserved group of GTP-binding proteins that form hetero-oligomeric complexes which assemble into filaments. These are essential for septin function, including their role in cytokinesis, cell division, exocytosis and membrane trafficking. Septin 2 (SEPT2) is a member of the septin family and has been associated with neurofibrillary tangles and other pathological features of senile plaques in Alzheimer's disease. An in silico analysis of the amino acid sequence of SEPT2 identified… CONTINUE READING


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