Self-assembly of amphipathic β-sheet peptides: insights and applications.

@article{Bowerman2012SelfassemblyOA,
  title={Self-assembly of amphipathic β-sheet peptides: insights and applications.},
  author={Charles J Bowerman and Bradley L Nilsson},
  journal={Biopolymers},
  year={2012},
  volume={98 3},
  pages={169-84}
}
Amphipathic peptides composed of alternating polar and nonpolar residues have a strong tendency to self-assemble into one-dimensional, amyloid-like fibril structures. Fibrils derived from peptides of general (XZXZ)(n) sequence in which X is hydrophobic and Z is hydrophilic adopt a putative β-sheet bilayer. The bilayer configuration allows burial of the… CONTINUE READING