Self-assembly of Abeta(1-42) into globular neurotoxins.

  title={Self-assembly of Abeta(1-42) into globular neurotoxins.},
  author={Brett Chromy and Richard J Nowak and Mary P. Lambert and Kirsten L. Viola and Lei Chang and Pauline T. Velasco and Bryan W. Jones and Sara J. Fernandez and Pascale N. Lacor and Peleg Horowitz and Caleb E. Finch and Grant A. Krafft and William L. Klein},
  volume={42 44},
Amyloid beta 1-42 (Abeta(1-42)) is a self-associating peptide that becomes neurotoxic upon aggregation. Toxicity originally was attributed to the presence of large, readily formed Abeta fibrils, but a variety of other toxic species are now known. The current study shows that Abeta(1-42) can self-assemble into small, stable globular assemblies free of fibrils and protofibrils. Absence of large molecules was verified by atomic force microscopy (AFM) and nondenaturing gel electrophoresis… CONTINUE READING


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