Self-assembly cationic nanoparticles based on cholesterol-grafted bioreducible poly(amidoamine) for siRNA delivery.

Abstract

In this study, a series of bioreducible poly(amidoamine)s grafting different percentages of cholesterol (rPAA-Ch14: 14%, rPAA-Ch29: 29%, rPAA-Ch57: 57% and rPAA-Ch87: 87%) was synthesized and used for siRNA delivery. These amphiphilic polymers were able to self-assemble into cationic nanoparticles in aqueous solution at low concentrations. The nanoparticle… (More)
DOI: 10.1016/j.biomaterials.2013.03.056

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Cite this paper

@article{Chen2013SelfassemblyCN, title={Self-assembly cationic nanoparticles based on cholesterol-grafted bioreducible poly(amidoamine) for siRNA delivery.}, author={Cheng-jun Chen and Jian-Cheng Wang and En-Yu Zhao and Ling-Yan Gao and Qiang Feng and Xiaoyan Liu and Zhi-Xia Zhao and Xiao-fei Ma and Wen-jie Hou and Liang-ren Zhang and Wan-liang Lu and Qiang Zhang}, journal={Biomaterials}, year={2013}, volume={34 21}, pages={5303-16} }