Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury.

@article{Tysseling2010SelfassemblingPA,
  title={Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury.},
  author={Vicki M Tysseling and Vibhu Sahni and E Thomas Pashuck and Derin V Birch and Amy R. T. H{\'e}bert and Catherine Czeisler and Samuel I. Stupp and John A Kessler},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 14},
  pages={3161-70}
}
Injection into the injured spinal cord of peptide amphiphile (PA) molecules that self-assemble and display the laminin epitope IKVAV at high density improved functional recovery after spinal cord injury (SCI) in two different species, rat and mouse, and in two different injury models, contusion and compression. The improvement required the IKVAV epitope and was not observed with the injection of an amphiphile displaying a nonbioactive sequence. To explore the mechanisms underlying these… CONTINUE READING

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