Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery.

@article{Kim2009SelfassemblingPA,
  title={Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery.},
  author={Jin-Ki Kim and Joel Anderson and Ho-wook Jun and Michael A. Repka and Seongbong Jo},
  journal={Molecular pharmaceutics},
  year={2009},
  volume={6 3},
  pages={978-85}
}
The aim of this study is to develop a bioresponsive cisplatin (CDDP) delivery system with a self-assembling peptide amphiphile (PA) comprising a cell-adhesive matrix metalloproteinase-2 (MMP-2)-sensitive GTAGLIGQRGDS and a fatty acid. A biomimetic CDDP-PA gel was spontaneously formed upon incubating a mixture of CDDP and the PA for 5 h at 37 degrees C. CDDP-PA gel formation was confirmed by rheological analysis. The structure of self-assembled CDDP-PA nanofibers inside the gel was determined by… CONTINUE READING