Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers.

@article{Davis2004SelfassemblingNA,
  title={Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers.},
  author={Mark E Davis and Suzie H Pun and Nathalie C Bellocq and Theresa M Reineke and Stephen R. Popielarski and Swaroop Ranjan Mishra and Jeremy David Heidel},
  journal={Current medicinal chemistry},
  year={2004},
  volume={11 2},
  pages={
          179-97
        }
}
Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have designed and prepared a tunable, non-viral nucleic acid delivery system that self-assembles with nucleic acids and centers around a new class of polymeric materials; namely, linear, water-soluble cyclodextrin-containing polymers. The relationships between polymer structure and gene delivery are illustrated, and the roles of the cyclodextrin… CONTINUE READING