Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly[(vinyl-3-(diethylamino)- propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft- poly(L-lactic acid): a novel carrier for transmucosal delivery of peptides.

@article{Simon2004SelfassemblingNF,
  title={Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly[(vinyl-3-(diethylamino)- propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft- poly(L-lactic acid): a novel carrier for transmucosal delivery of peptides.},
  author={Michael Simon and Matthias Wittmar and Udo Bakowsky and Thomas R. Kissel},
  journal={Bioconjugate chemistry},
  year={2004},
  volume={15 4},
  pages={841-9}
}
The design of carriers for protein delivery that provide protection against enzymatic degradation and facilitate protein transport across epithelial surfaces, thus avoiding parenteral administration, remains a challenge. Self-assembling nanoscale protein/polymer complexes might present a promising approach. We synthesized water-soluble, amphiphilic polyesters, poly[(vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(L-lactic acid), containing a positively… CONTINUE READING