Self-assembling Peptide Scaffolds Promote Enamel Remineralization

@article{Kirkham2007SelfassemblingPS,
  title={Self-assembling Peptide Scaffolds Promote Enamel Remineralization},
  author={J. Kirkham and A. Firth and D. Vernals and N. Boden and C. Robinson and R. Shore and S. Brookes and A. Aggeli},
  journal={Journal of Dental Research},
  year={2007},
  volume={86},
  pages={426 - 430}
}
Rationally designed β-sheet-forming peptides that spontaneously form three-dimensional fibrillar scaffolds in response to specific environmental triggers may potentially be used in skeletal tissue engineering, including the treatment/prevention of dental caries, via bioactive surface groups. We hypothesized that infiltration of caries lesions with monomeric low-viscosity peptide solutions would be followed by in situ polymerization triggered by conditions of pH and ionic strength, providing a… Expand
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