Self-assembling Peptide Scaffolds Promote Enamel Remineralization

@article{Kirkham2007SelfassemblingPS,
  title={Self-assembling Peptide Scaffolds Promote Enamel Remineralization},
  author={J. Kirkham and A. Firth and D. Vernals and N. Boden and C. Robinson and R. Shore and S. Brookes and A. Aggeli},
  journal={Journal of Dental Research},
  year={2007},
  volume={86},
  pages={426 - 430}
}
Rationally designed β-sheet-forming peptides that spontaneously form three-dimensional fibrillar scaffolds in response to specific environmental triggers may potentially be used in skeletal tissue engineering, including the treatment/prevention of dental caries, via bioactive surface groups. We hypothesized that infiltration of caries lesions with monomeric low-viscosity peptide solutions would be followed by in situ polymerization triggered by conditions of pH and ionic strength, providing a… Expand
247 Citations

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to determine whether Fluoride varnish + calcium (Clinpro White Varnish) and polipeptide solution (Curodont Repair) are effective in the treatment of… Expand
ConditionsWhite Spot Lesions
InterventionOther
Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide
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The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin
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