Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections.

@article{Smiramoth2012SelfassembledSP,
  title={Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections.},
  author={Nicolas S{\'e}miramoth and Chiara di Meo and Fatima Zouhiri and Fatouma Sa{\"i}d-Hassane and Sabrina Valetti and Roseline Gorges and Val{\'e}rie Nicolas and Jacques H. Poupaert and Sylvie Chollet-Martin and Didier Desma{\"e}le and Ruxandra Gref and Patrick Couvreur},
  journal={ACS nano},
  year={2012},
  volume={6 5},
  pages={3820-31}
}
We describe here new nanoparticles based on the bioconjugation of penicillin G to squalene in order to overcome severe intracellular infections by pathogen bacteria whose mechanism of resistance arises from the poor intracellular diffusion of several antibiotics. Two different squalene-penicillin G conjugates were synthesized (pH-sensitive and pH-insensitive), and their self-assembly as nanoparticles was investigated through morphology and stability studies. These nanoparticles had a size of… CONTINUE READING
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