Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces

@article{Prime1991SelfassembledOM,
  title={Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces},
  author={Kevin L. Prime and George M. Whitesides},
  journal={Science},
  year={1991},
  volume={252},
  pages={1164 - 1167}
}
Self-assembled monolayers (SAMs) of omega-functionalized long-chain alkanethiolates on gold films are excellent model systems with which to study the interactions of proteins with organic surfaces. Monolayers containing mixtures of hydrophobic (methyl-terminated) and hydrophilic [hydroxyl-, maltose-, and hexa(ethylene glycol)-terminated] alkanethiols can be tailored to select specific degrees of adsorption: the amount of protein adsorbed varies monotonically with the composition of the… 

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