Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces.

  title={Self-assembled organic monolayers: model systems for studying adsorption of proteins at surfaces.},
  author={K L Prime and George M Whitesides},
  volume={252 5009},
Self-assembled monolayers (SAMs) of omega-functionalized long-chain alkanethiolates on gold films are excellent model systems with which to study the interactions of proteins with organic surfaces. Monolayers containing mixtures of hydrophobic (methyl-terminated) and hydrophilic [hydroxyl-, maltose-, and hexa(ethylene glycol)-terminated] alkanethiols can be tailored to select specific degrees of adsorption: the amount of protein adsorbed varies monotonically with the composition of the… CONTINUE READING

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