Self-assembled nanoparticles comprising aptide-SN38 conjugates for use in targeted cancer therapy.

@article{Kim2016SelfassembledNC,
  title={Self-assembled nanoparticles comprising aptide-SN38 conjugates for use in targeted cancer therapy.},
  author={Hyungjun Kim and Yonghyun Lee and Sukmo Kang and Minsuk Choi and Soyoung Lee and Sunghyun Kim and Vipul Gujrati and Jinjoo Kim and Sangyong Jon},
  journal={Nanotechnology},
  year={2016},
  volume={27 48},
  pages={
          48LT01
        }
}
Self-assembled nanoparticles (NPs) have been intensively utilized as cancer drug delivery carriers because hydrophobic anticancer drugs may be efficiently loaded into the particle cores. In this study, we synthesized and evaluated the therapeutic index of self-assembled NPs chemically conjugated to a fibronectin extra domain B-specific peptide (APTEDB) and an anticancer agent SN38. The APTEDB-SN38 formed self-assembled structures with a diameter of 58 ± 3 nm in an aqueous solution and displayed… CONTINUE READING