Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery

@inproceedings{Raja2016SelfassembledNB,
  title={Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery},
  author={Mazhar Ali Raja and Shah Zeenat and Muhammad Arif and Chen-Guang Liu},
  booktitle={International journal of nanomedicine},
  year={2016}
}
Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acrylonitrile (AN) and hydrophilic arginine (Arg); the synthesized conjugate (AN-CS-Arg), which was well… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 102 references

Arginine and acrylonitrile modified chitosan nanoparticles for anticancer drug

L Yin, T Su, J Chang
2014
View 1 Excerpt

Similar Papers

Loading similar papers…