Self-assembled nanoparticle probes for recognition and detection of biomolecules.

  title={Self-assembled nanoparticle probes for recognition and detection of biomolecules.},
  author={Dustin J Maxwell and Jason R Taylor and Shuming Nie},
  journal={Journal of the American Chemical Society},
  volume={124 32},
Colloidal gold nanocrystals have been used to develop a new class of nanobiosensors that is able to recognize and detect specific DNA sequences and single-base mutations in a homogeneous format. At the core of this biosensor is a 2.5-nm gold nanoparticle that functions as both a nano-scaffold and a nano-quencher (efficient energy acceptor). Attached to this core are oligonucleotide molecules labeled with a thiol group at one end and a fluorophore at the other. This hybrid bio/inorganic… CONTINUE READING
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