Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo.

@article{Mu2010SelfassembledGN,
  title={Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo.},
  author={Chunyao Jenny Mu and David A. LaVan and Robert S Langer and Bruce R. Zetter},
  journal={ACS nano},
  year={2010},
  volume={4 3},
  pages={1511-20}
}
Target-activatable fluorogenic probes based on gold nanoparticles (AuNPs) functionalized with self-assembled heterogeneous monolayers of dye-labeled peptides and poly(ethylene glycol) have been developed to visualize proteolytic activity in vivo. A one-step synthesis strategy that allows simple generation of surface-defined AuNP probe libraries is presented as a means of tailoring and evaluating probe characteristics for maximal fluorescence enhancement after protease activation. Optimal AuNP… CONTINUE READING

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