Self-assembled complex of probe peptide--E. Coli RNA I conjugate and nano graphene oxide for apoptosis diagnosis.

@article{Kong2012SelfassembledCO,
  title={Self-assembled complex of probe peptide--E. Coli RNA I conjugate and nano graphene oxide for apoptosis diagnosis.},
  author={Won Ho Kong and Dong Kyung Sung and Ki Su Kim and Ho Sang Jung and Eun Ji Gho and Seok-Hyun Yun and Sei Kwang Hahn},
  journal={Biomaterials},
  year={2012},
  volume={33 30},
  pages={
          7556-64
        }
}
Caspase-3 plays an important role in the initiation and propagation of apoptosis which is involved in various kinds of diseases including neurodegenerative diseases and inflammatory diseases. The capase-3 cleavable site of Asp-Glu-Val-Asp (DEVD) connected to a partial sequence of Escherichia coli RNAI was labeled with tetramethyl-6-carboxyrhodamine (TAMRA) as an optical probe. Graphene oxide (GO) was synthesized by a modified Hummer's method and exploited for the preparation of nano-sized GO… CONTINUE READING
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