Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy.

@article{Yuan2015SelfassembledPM,
  title={Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy.},
  author={Ahu Yuan and Xuefeng Qiu and Xiaolei Tang and Wei Liu and Jinhui Wu and Yiqiao Hu},
  journal={Biomaterials},
  year={2015},
  volume={51},
  pages={184-193}
}
IR-780, a representative hydrophobic near-infrared (NIR) fluorescence dye, is capable of fluorescently imaging and photothermal therapy in vitro and in vivo. However, insolubility in all pharmaceutically acceptable solvents limits its further biological applications. To increase solubility, we developed a novel self-assembled IR-780 containing micelle (PEG-IR-780-C13) based on the structural modification of IR-780. Briefly, a hydrophilic PEG2000 was modified on the one side of IR-780, and the… CONTINUE READING