Self-assembled BolA-like amphiphilic peptides as viral-mimetic gene vectors for cancer cell targeted gene delivery.

@article{Chen2013SelfassembledBA,
  title={Self-assembled BolA-like amphiphilic peptides as viral-mimetic gene vectors for cancer cell targeted gene delivery.},
  author={Jing-xiao Chen and Xiao-Ding Xu and Shuo Yang and Juan Yang and R Jin-Cong Zhuo and Xianzheng Zhang},
  journal={Macromolecular bioscience},
  year={2013},
  volume={13 1},
  pages={84-92}
}
In this study, two types of BolA-like amphiphilic peptides with dual ligands comprising a tumor-targeting moiety of RGD sequence and a cell-penetrating moiety of R8 sequence are designed and synthesized as gene vectors. The BolA-structural peptide carriers can self-assemble into spherical nanoparticles with a hydrophilic core and shell, which are similar to the viral capsid and can bind plasmid DNA in an aqueous medium to form viral-mimetic complexes. It is found that the BolA-like dual ligands… CONTINUE READING
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