Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.

@article{BaileyBucktrout2013SelfantigendrivenAI,
  title={Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.},
  author={Samantha L. Bailey-Bucktrout and Marc Mart{\'i}nez-Llordella and Xuyu Zhou and Bryan A. Anthony and Wendy L. Rosenthal and Herv{\'e} Luche and Hans Joerg Fehling and Jeffrey A Bluestone},
  journal={Immunity},
  year={2013},
  volume={39 5},
  pages={949-62}
}
Stable Foxp3 expression is crucial for regulatory T (Treg) cell function. We observed that antigen-driven activation and inflammation in the CNS promoted Foxp3 instability selectively in the autoreactive Treg cells that expressed high amounts of Foxp3 before experimental autoimmune encephalitis induction. Treg cells with a demethylated Treg-cell-specific demethylated region in the Foxp3 locus downregulated Foxp3 transcription in the inflamed CNS during the induction phase of the response… CONTINUE READING

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Diabetes TrialNet and the Immune Tolerance Network

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