Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats.

@article{Devine1994SelfadministrationOM,
  title={Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats.},
  author={Darragh P. Devine and Roy A. Wise},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 4},
  pages={
          1978-84
        }
}
Intracranial self-administration of mu- and delta-opioid agonists was demonstrated in male Long-Evans rats. Independent groups were allowed to lever-press for ventral tegmental area (VTA) microinfusions of morphine, the selective mu agonist [D-Ala2,N-Me-Phe4-Gly5-ol]-enkephalin (DAMGO), the selective delta-agonist [D-Pen2,D-Pen5]-enkephalin (DPDPE), or ineffective drug vehicle. Morphine, DAMGO, and DPDPE were each effective in establishing and maintaining lever-pressing habits. Lever-pressing… CONTINUE READING

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