Self-adjusting synthetic gene circuit for correcting insulin resistance

@inproceedings{Ye2017SelfadjustingSG,
  title={Self-adjusting synthetic gene circuit for correcting insulin resistance},
  author={Haifeng Ye and Mingqi Xie and Shuai Xue and Ghislaine Charpin-El Hamri and Jianli Yin and Henryk Zulewski and Martin Fussenegger},
  booktitle={Nature biomedical engineering},
  year={2017}
}
By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functionally rewiring the mitogen-activated protein kinase (MAPK) signalling pathway to produce MAPK-mediated activation of the hybrid transcription factor TetR-ELK1, we assembled a synthetic insulin… CONTINUE READING

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