Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen

  title={Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen},
  author={Teresa A. Colella and Timothy N J Bullock and Liane Brauch Russell and David W Mullins and Willem W. Overwijk and Chance John Luckey and Richard A. Pierce and Nicholas P Restifo and Victor H Engelhard},
  journal={The Journal of Experimental Medicine},
  pages={1221 - 1232}
The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201(+) melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also expressed in melanocytes. To gain information about immunoreactivity and self-tolerance to this antigen, we established a model using the murine tyrosinase-derived homologue of this peptide FMDGTMSQV, together with transgenic mice expressing the HLA-A*0201… CONTINUE READING
80 Citations
66 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 80 extracted citations


Publications referenced by this paper.
Showing 1-10 of 66 references

High frequency of skin-homing melanocyte on F ebuary 23

  • G. S. Ogg, D. P. Rod, P. Romero, J. L. Chen, V. Cerundolo
  • Published April
  • 1998

Similar Papers

Loading similar papers…