Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen

@article{Colella2000SelfToleranceTT,
  title={Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen},
  author={Teresa A. Colella and Timothy N J Bullock and Liane Brauch Russell and David W Mullins and Willem W. Overwijk and Chance John Luckey and Richard A. Pierce and Nicholas P Restifo and Victor H Engelhard},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={1221 - 1232}
}
The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201(+) melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also expressed in melanocytes. To gain information about immunoreactivity and self-tolerance to this antigen, we established a model using the murine tyrosinase-derived homologue of this peptide FMDGTMSQV, together with transgenic mice expressing the HLA-A*0201… CONTINUE READING
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High frequency of skin-homing melanocyte on F ebuary 23

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