Self-Sustained Replication of an RNA Enzyme

@article{Lincoln2009SelfSustainedRO,
  title={Self-Sustained Replication of an RNA Enzyme},
  author={Tracey A. Lincoln and G. F. Joyce},
  journal={Science},
  year={2009},
  volume={323},
  pages={1229 - 1232}
}
  • Tracey A. Lincoln, G. F. Joyce
  • Published 2009
  • Biology, Medicine
  • Science
  • An RNA enzyme that catalyzes the RNA-templated joining of RNA was converted to a format whereby two enzymes catalyze each other's synthesis from a total of four oligonucleotide substrates. These cross-replicating RNA enzymes undergo self-sustained exponential amplification in the absence of proteins or other biological materials. Amplification occurs with a doubling time of about 1 hour and can be continued indefinitely. Populations of various cross-replicating enzymes were constructed and… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Cross-catalytic replication of an RNA ligase ribozyme.
    • 95
    • PDF
    A self-replicating ligase ribozyme
    • N. Paul, G. F. Joyce
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 178
    • PDF
    Prebiotic chemistry and the origin of the RNA world.
    • L. Orgel
    • Biology, Medicine
    • Critical reviews in biochemistry and molecular biology
    • 2004
    • 746
    • PDF
    The antiquity of RNA-based evolution
    • 766
    • PDF
    The origin of the genetic code.
    • 1,446
    Advances in Experimental Social Psychology
    • 393
    Nature
    • R. Rosenfeld
    • Medicine
    • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
    • 2009
    • 54,496