• DOI:10.1126/science.1167856
Corpus ID: 206517215

Self-Sustained Replication of an RNA Enzyme

@article{Lincoln2009SelfSustainedRO,
  title={Self-Sustained Replication of an RNA Enzyme},
  author={Tracey A. Lincoln and G. F. Joyce},
  journal={Science},
  year={2009},
  volume={323},
  pages={1229 - 1232}
}

Tracey A. Lincoln, G. F. Joyce

Published 2009

Biology, Medicine

Science

An RNA enzyme that catalyzes the RNA-templated joining of RNA was converted to a format whereby two enzymes catalyze each other's synthesis from a total of four oligonucleotide substrates. These cross-replicating RNA enzymes undergo self-sustained exponential amplification in the absence of proteins or other biological materials. Amplification occurs with a doubling time of about 1 hour and can be continued indefinitely. Populations of various cross-replicating enzymes were constructed and… CONTINUE READING

View on AAAS

europepmc.org

Save to Library

Create Alert

Cite

Launch Research Feed