Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.

@article{Cui2018SelfResistanceDM,
  title={Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.},
  author={Zheng Cui and Xia-Chang Wang and Xiaodong Liu and Anke Lemke and Stefan Koppermann and Christian Ducho and J{\"u}rgen Rohr and Jon S Thorson and Steven G Van Lanen},
  journal={Antimicrobial agents and chemotherapy},
  year={2018},
  volume={62 7}
}
Muraymycins are antibacterial natural products from Streptomyces spp. that inhibit translocase I (MraY), which is involved in cell wall biosynthesis. Structurally, muraymycins consist of a 5'-C-glycyluridine (GlyU) appended to a 5″-amino-5″-deoxyribose (ADR), forming a disaccharide core that is found in several peptidyl nucleoside inhibitors of MraY. For… CONTINUE READING