Self-Organized Criticality Theory of Autoimmunity

  title={Self-Organized Criticality Theory of Autoimmunity},
  author={Ken Tsumiyama and Yumi Miyazaki and Shunichi Shiozawa},
  booktitle={PloS one},
BACKGROUND The cause of autoimmunity, which is unknown, is investigated from a different angle, i.e., the defect in immune 'system', to explain the cause of autoimmunity. METHODOLOGY/PRINCIPAL FINDINGS Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4(+) T cells led to the development of autoantibody-inducing CD4(+) T (aiCD4(+) T) cell which had undergone T cell receptor (TCR) revision and was… CONTINUE READING
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