Self-Assembly and DNA Binding of the Blocking Factor in X Chromosome Inactivation

  title={Self-Assembly and DNA Binding of the Blocking Factor in X Chromosome Inactivation},
  author={Mario Nicodemi and Antonella Prisco},
  journal={PLoS Computational Biology},
  pages={372 - 373}
X chromosome inactivation (XCI) is the phenomenon occurring in female mammals whereby dosage compensation of X-linked genes is obtained by transcriptional silencing of one of their two X chromosomes, randomly chosen during early embryo development. The earliest steps of random X-inactivation, involving counting of the X chromosomes and choice of the active and inactive X, are still not understood. To explain "counting and choice," the longstanding hypothesis is that a molecular complex, a… CONTINUE READING


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A symmetry breaking model for counting and choice in X-inactivation

  • M Nicodemi, A Prisco
  • Phys Rev Lett
  • 2007
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