Self-Administration of cocaine-opioid combinations by rhesus monkeys: evaluation of the role of mu receptor efficacy using labor supply analysis.

@article{Rowlett2005SelfAdministrationOC,
  title={Self-Administration of cocaine-opioid combinations by rhesus monkeys: evaluation of the role of mu receptor efficacy using labor supply analysis.},
  author={James K. Rowlett and Joshua S. Rodefer and Roger D. Spealman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2005},
  volume={312 3},
  pages={1289-97}
}
Cocaine and heroin often are abused by self-administering the drugs in combination as a "speedball". We evaluated the extent to which intrinsic efficacy at the mu-opioid receptor influences combined cocaine-opioid self-administration and used the behavioral economic model termed "labor supply" to quantitatively evaluate the reinforcing effects of cocaine-opioid combinations. Rhesus monkeys (n = 8) were trained under a progressive-ratio schedule of i.v. cocaine injection in which the response… CONTINUE READING

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