Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

@article{Becker2006SelfrenewalOH,
  title={Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase},
  author={Klaus A. Becker and P. Ghule and J. A. Therrien and J. Lian and J. Stein and A. V. van Wijnen and G. Stein},
  journal={Journal of Cellular Physiology},
  year={2006},
  volume={209}
}
Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study we show that human ES cells (H1 and H9; NIH‐designated WA01 and WA09) rapidly proliferate due to a very short overall cell cycle (15–16 h) compared to somatic cells (e.g., normal diploid IMR90 fibroblasts and NT‐2 teratocarcinoma cells). The human ES cell cycle maintains the four canonical cell cycle… Expand
398 Citations
Reprogramming the pluripotent cell cycle: Restoration of an abbreviated G1 phase in human induced pluripotent stem (iPS) cells
  • 76
Human embryonic stem cells are pre‐mitotically committed to self‐renewal and acquire a lengthened G1 phase upon lineage programming
  • 56
Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells.
  • 108
  • PDF
Lengthened G1 phase indicates differentiation status in human embryonic stem cells.
  • 122
  • PDF
The brevity of G1 is an intrinsic determinant of naïve pluripotency
  • Highly Influenced
The abbreviated pluripotent cell cycle
  • 93
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.
  • 1,470
  • PDF
Cell cycle control of embryonic stem cells
  • 300
Derivation, Characterization, and Differentiation of Human Embryonic Stem Cells
  • 298
Cell Cycle Features of Primate Embryonic Stem Cells
  • 183
  • PDF
Derivation, growth and applications of human embryonic stem cells.
  • 152
  • PDF
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities
  • 357
  • PDF
Comparative transcriptional profiling of two human embryonic stem cell lines
  • 79
  • PDF
Characterization and differentiation of human embryonic stem cells.
  • 303
Gene expression in human embryonic stem cell lines: unique molecular signature.
  • 416
...
1
2
3
4
...