• DOI:10.1002/jcp.20776
Corpus ID: 24908771

Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

@article{Becker2006SelfrenewalOH,
  title={Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase},
  author={Klaus A. Becker and P. Ghule and J. A. Therrien and J. Lian and J. Stein and A. V. van Wijnen and G. Stein},
  journal={Journal of Cellular Physiology},
  year={2006},
  volume={209}
}

• Klaus A. Becker, P. Ghule, +4 authors G. Stein
• Published 2006
• Biology, Medicine
• Journal of Cellular Physiology

Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study we show that human ES cells (H1 and H9; NIH‐designated WA01 and WA09) rapidly proliferate due to a very short overall cell cycle (15–16 h) compared to somatic cells (e.g., normal diploid IMR90 fibroblasts and NT‐2 teratocarcinoma cells). The human ES cell cycle maintains the four canonical cell cycle… Expand

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