Self‐healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches

@inproceedings{Mazzara2019SelfhealingEA,
  title={Self‐healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches},
  author={John Maxwell Mazzara and Lukasz J. Ochyl and Justin K. Y. Hong and James J Moon and Mark R. Prausnitz and Steven P Schwendeman},
  booktitle={Bioengineering & translational medicine},
  year={2019}
}
There is an urgent need to reduce reliance on hypodermic injections for many vaccines to increase vaccination safety and coverage. Alternative approaches include controlled release formulations, which reduce dosing frequencies, and utilizing alternative delivery devices such as microneedle patches (MNPs). This work explores development of controlled release microparticles made of poly (lactic-co-glycolic acid) (PLGA) that stably encapsulate various antigens though aqueous active self-healing… CONTINUE READING
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