Self‐administration of cocaine and the cocaine analog RTI‐113: Relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys

@article{Wilcox2002SelfadministrationOC,
  title={Self‐administration of cocaine and the cocaine analog RTI‐113: Relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys},
  author={Kristin M. Wilcox and Kimberly P. Lindsey and John R. Votaw and Mark M. Goodman and Laurent Martarello and F. Ivy Carroll and Leonard Lee Howell},
  journal={Synapse},
  year={2002},
  volume={43}
}
Dopaminergic mechanisms are thought to play a central role in the reinforcing effects of cocaine. The present study examined the reinforcing effects of 3β‐(4‐chlorophenyl)tropane‐2β‐carboxylic acid phenyl ester (RTI‐113), a long‐acting, selective, high‐affinity dopamine uptake inhibitor. Additionally, the effects of RTI‐113 pretreatment on cocaine self‐administration were determined. Monkeys were trained to respond under a second‐order schedule for intravenous cocaine administration (0.10 or 0… 
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