Self/nonself perception, reproduction and the extended MHC.

@article{Ziegler2010SelfnonselfPR,
  title={Self/nonself perception, reproduction and the extended MHC.},
  author={Andreas Ziegler and Pablo S C Santos and Thomas Kellermann and Barbara Uchańska-Ziegler},
  journal={Self/nonself},
  year={2010},
  volume={1 3},
  pages={176-191}
}
Self/nonself perception governs mate selection in most eukaryotic species. It relies on a number of natural barriers that act before, during and after copulation. These hurdles prevent a costly investment into an embryo with potentially suboptimal genetic and immunological properties and aim at discouraging fertilization when male and female gametes exhibit extensive sharing of alleles. Due to the fact that several genes belonging to the extended major histocompatibility complex (xMHC) carry… CONTINUE READING
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