Selenoproteins in Nervous System Development and Function

  title={Selenoproteins in Nervous System Development and Function},
  author={Matthew W. Pitts and China N. Byrns and Ashley N. Ogawa-Wong and Penny M Kremer and Marla J. Berry},
  journal={Biological Trace Element Research},
Selenoproteins are a distinct class of proteins that are characterized by the co-translational incorporation of selenium (Se) in the form of the 21st amino acid selenocysteine. Selenoproteins provide a key defense against oxidative stress, as many of these proteins participate in oxidation-reduction reactions neutralizing reactive oxygen species, where selenocysteine residues act as catalytic sites. Many selenoproteins are highly expressed in the brain, and mouse knockout studies have… CONTINUE READING


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