Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.

@article{Sun2001SelenoproteinOW,
  title={Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.},
  author={Q A Sun and L Kirnarsky and Simon Sherman and Vadim N. Gladyshev},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 7},
  pages={3673-8}
}
Thioredoxin (Trx) and glutathione (GSH) systems are considered to be two major redox systems in animal cells. They are reduced by NADPH via Trx reductase (TR) or oxidized GSH (GSSG) reductase and further supply electrons for deoxyribonucleotide synthesis, antioxidant defense, and redox regulation of signal transduction, transcription, cell growth, and apoptosis. We cloned and characterized a pyridine nucleotide disulfide oxidoreductase, Trx and GSSG reductase (TGR), that exhibits specificity… CONTINUE READING