Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.

@article{Stenvall2011SelenoproteinTA,
  title={Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.},
  author={J{\"o}rgen Stenvall and Juan Carlos Fierro-Gonz{\'a}lez and Peter Swoboda and Karunakar Saamarthy and Qing Cheng and Briseida Cacho-Valadez and Elias S J Arn{\'e}r and Olof P Persson and Antonio Miranda-Vizuete and Simon Tuck},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 3},
  pages={1064-9}
}
Selenoproteins, in particular thioredoxin reductase, have been implicated in countering oxidative damage occurring during aging but the molecular functions of these proteins have not been extensively investigated in different animal models. Here we demonstrate that TRXR-1 thioredoxin reductase, the sole selenoprotein in Caenorhabditis elegans, does not protect against acute oxidative stress but functions instead together with GSR-1 glutathione reductase to promote the removal of old cuticle… CONTINUE READING

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The cuticle. WormBook, ed. The C. elegans Research Community, WormBook,doi/10.1895/wormbook.1.138.1, http://www.wormbook.org

  • AP Page, IL Johnstone
  • Accessed March
  • 2007

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