Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.

@article{Sengupta2009SelenoproteinTD,
  title={Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.},
  author={Aniruddha Sengupta and Bradley A. Carlson and Vyacheslav M Labunskyy and Vadim N. Gladyshev and Dolph Lee Hatfield},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2009},
  volume={87 6},
  pages={953-61}
}
Mammalian selenoproteins have diverse functions, cellular locations, and evolutionary histories, but all use the amino acid selenocysteine (Sec), often present in the enzyme's active site. Only about half of mammalian selenoproteins have been functionally characterized, with most being oxidoreductases. The cellular role of selenoprotein T (SelT), manifesting a CxxU motif in a thioredoxin-like fold and localized to Golgi and the endoplasmic reticulum, is not known. To examine its biological… CONTINUE READING
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