Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.

@article{Chen2017SelenoproteinPI,
  title={Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance.},
  author={Miaoxin Chen and Bo Liu and David Wilkinson and Amy T Hutchison and Campbell H Thompson and Gary A Wittert and Leonie K Heilbronn},
  journal={Obesity research & clinical practice},
  year={2017},
  volume={11 2},
  pages={
          227-232
        }
}
Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N=29) or overweight/obese (N=34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P<0.001), and associated with insulin resistance by HOMA-IR and by clamp, but… CONTINUE READING

From This Paper

Topics from this paper.
1 Citations
0 References
Similar Papers